Which statement regarding Stevens-Johnson syndrome is accurate?

Stevens-Johnson syndrome (SJS) is recognized as a severe condition characterized by extensive mucocutaneous involvement. The accurate statement is that diagnosis requires involvement of ocular or genital mucosa. In SJS, there is significant damage to the skin and mucous membranes, and the inclusion of these areas is critical for defining the condition. This involvement helps differentiate SJS from other skin disorders that have less severe manifestations and can guide appropriate treatment strategies.

The rationale is that both the ocular and genital areas are highly sensitive to tissue damage, and involvement can lead to complications such as vision loss or reproductive issues. It is essential to recognize the mucosal involvement, as it can indicate the systemic nature of the syndrome and the need for aggressive management.

Other statements do not align with the clinical understanding of SJS. For instance, while ocular blistering may occur, it is distinctly different from presentations seen in conditions like bullous pemphigoid, which primarily affects the skin without significant mucosal involvement. The etiology of SJS is often drug-related rather than linked to acute infections, which is a critical aspect of its presentation. Furthermore, while SJS shares similarities with erythema multiforme, it is generally considered a more severe manifestation rather