Which of the following statements regarding Hepatitis B vaccines is true?

The correct statement about the Hepatitis B vaccine is that antibody response to hepatitis B surface antigen should be performed 1-2 months after the third vaccine dose. This post-vaccination serological testing is important to ensure that the individual has developed an adequate immune response to the vaccine. A protective titer is typically considered to be an antibody level greater than or equal to 10 mIU/mL. Testing at this interval allows healthcare providers to determine if a person has effectively responded to the vaccination series.

The rationale behind the timing for testing is that it provides a sufficient period for the immune system to respond to the vaccine stimulus after the last dose, thus ensuring accurate assessment of the vaccine's efficacy. If the individual does not show sufficient antibodies, they may require further doses of the vaccine.

In contrast, the first statement about the timing of the first two doses is incorrect, as Dose 1 and Dose 2 are recommended to be administered at least 1 month apart. The second statement contains an error as well; while Dose 3 is typically administered 6 months after the first dose, it does not follow that it is specifically 3 months after the second dose. The final statement about booster doses is misleading; routine booster doses for the Hep