Which dermatologic condition is known for causing generalized widening of the periodontal ligament space?

Systemic sclerosis, also known as scleroderma, is a chronic autoimmune condition characterized by the hardening and tightening of the skin and connective tissues. One of the dental manifestations of systemic sclerosis includes the generalized widening of the periodontal ligament space. This occurs due to collagen deposition and fibrotic changes in the connective tissues, which can lead to alterations in the periodontal structures.

In patients with systemic sclerosis, the inflammatory and fibrotic processes can affect the periodontal ligament, causing it to appear widened when viewed radiographically. This change is often associated with other oral findings, such as xerostomia (dry mouth) and difficulties with oral hygiene.

The other conditions listed may have various dental or oral manifestations, but they do not specifically lead to the generalized widening of the periodontal ligament space in the same manner as systemic sclerosis. For example, Ehlers-Danlos syndrome is associated with hypermobility and fragile connective tissues, but it does not typically cause the distinct periodontal changes seen in systemic sclerosis. Tuberous sclerosis generally leads to dental enamel pitting and other growths or tumors affecting the mouth, while epidermolysis bullosa primarily affects the skin and can cause blistering but does not have a direct association with periodontal ligament widening.